Literature review on malaria parasite
The screen identified several small molecules that inhibit parasite load in liver cells, some with nanomolar efficacy, and each compound was subsequently assessed for activity against blood-stage malaria.
- Literature Review: Targeting Kinases Essential to Malaria Parasites;
- Review Articles.
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Most of the screening hits inhibited both liver- and blood-stage malaria parasites, which have dissimilar gene expression profiles and infect different host cells. Evaluation of existing kinase activity profiling data for the library members suggests that several kinases are essential to malaria parasites, including cyclin-dependent kinases CDKs , glycogen synthase kinases, and phosphoinositidekinases.
CDK inhibitors were found to bind to Plasmodium protein kinase 5, but it is likely that these compounds target multiple parasite kinases. The dual-stage inhibition of the identified kinase inhibitors makes them useful chemical probes and promising starting points for antimalarial development.
Targeting Kinases Essential to Malaria Parasites
The journal includes a "Literature Search and Review" column that identifies published papers of note and discusses their importance. GEN presents here one article that was analyzed in the " Literature Search and Review " column, a paper published in Chembiochem titled "Chemical interrogation of the malaria kinome. Log in to leave a comment.
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Top 10 Companies Leveraging Gene Editing in All Supplement. Modular Bioprocessing Makes Adaptability a Snap. Cerebral malaria is a severe form of malaria that may be associated with acute and chronic general behavioural, neurological or neuropsychiatric manifestations.
However, scientific literature appears to have made only a limited if any attempt at distinguishing the central nervous system effects of malaria infection from those of antimalaria drugs, and those that may occur due to possible interactions between the parasite and the drugs; as it relates to behaviour, brain neurochemistry, and neuromorphology. In this narrative review, we examine available literature dealing with the subject of the central effects of: The plasmodium parasite, antimalaria drugs, and interactions between drugs and the parasite; with a view to delineating the behavioural, neurochemical and neuromorphological changes that may occur due the infection, the drugs, and with the interactions of the drugs with the parasites inside the host.
Keywords: Cerebral malaria, inflammation, malaria, memory, neurology, plasmodium species. Abstract: Background: Recorded history shows that malaria has plagued mankind for centuries, if not millennia, with the disease infecting and affecting several body tissues, organs and systems; including the central nervous system.
Volume 18 , Issue 3 , Journal Home.
Graphical Abstract: Abstract: Background: Recorded history shows that malaria has plagued mankind for centuries, if not millennia, with the disease infecting and affecting several body tissues, organs and systems; including the central nervous system.